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Table 2 Summary of selected temporal phosphoproteomic data

From: Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling

Protein

Residue

Wolf-Yadlin et al. (2007)

VanMeter et al. (2009)

Ciaccio et al. (2010)

ERBB1 (EGFR)

    
 

Y845

  

X

 

Y992

 

X

 
 

Y998

X

  
 

Y1045

X

  
 

Y1068

 

X

X

 

Y1086

  

X

 

Y1148

X

X

 
 

Y1173

X

X

X

ERBB2 (HER2)

    
 

Y1221/1222

  

X

 

Y1248

X

X

 

ERBB3 (HER3)

    
 

Y1289

  

X

 

Y1328

   

ERBB4

    
 

Y1284

  

X

Shc1

    
 

Y239/240

X

 

X

 

Y317

X

X

X

Raf-1

    
 

S289/296/301

  

X

 

S338

  

X

MEK1/2

    
 

S217/T221

  

X

ERK1/2

    
 

T202/Y204

X

X

X

Gab1

    
 

Y373

X

  
 

Y406

X

  
 

Y627

X

X

X

 

Y659

X

  

Akt1

    
 

T308

 

X

X

 

S473

 

X

X

  1. Time courses have been measured for many of the serine, threonine and tyrosine (S/T/Y) residues considered in the model presented here. Here, we focus on three studies that applied distinct experimental techniques to measure time courses of phosphorylation for specific S/T/Y sites. In the study of Wolf-Yadlin et al.[45], the technique of selected reaction monitoring and quantitative mass spectrometry was applied. In the study of VanMeter et al.[46], the technique of reverse phase protein array was applied. In the study of Ciaccio et al.[47], the technique of microwestern array was applied. An ‘X’ entry in this table signifies that a time course of phosphorylation for the indicated residue was measured in the indicated study.