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Table 2 Summary of selected temporal phosphoproteomic data

From: Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling

Protein Residue Wolf-Yadlin et al. (2007) VanMeter et al. (2009) Ciaccio et al. (2010)
ERBB1 (EGFR)     
  Y845    X
  Y992   X  
  Y998 X   
  Y1045 X   
  Y1068   X X
  Y1086    X
  Y1148 X X  
  Y1173 X X X
ERBB2 (HER2)     
  Y1221/1222    X
  Y1248 X X  
ERBB3 (HER3)     
  Y1289    X
  Y1328    
ERBB4     
  Y1284    X
Shc1     
  Y239/240 X   X
  Y317 X X X
Raf-1     
  S289/296/301    X
  S338    X
MEK1/2     
  S217/T221    X
ERK1/2     
  T202/Y204 X X X
Gab1     
  Y373 X   
  Y406 X   
  Y627 X X X
  Y659 X   
Akt1     
  T308   X X
  S473   X X
  1. Time courses have been measured for many of the serine, threonine and tyrosine (S/T/Y) residues considered in the model presented here. Here, we focus on three studies that applied distinct experimental techniques to measure time courses of phosphorylation for specific S/T/Y sites. In the study of Wolf-Yadlin et al.[45], the technique of selected reaction monitoring and quantitative mass spectrometry was applied. In the study of VanMeter et al.[46], the technique of reverse phase protein array was applied. In the study of Ciaccio et al.[47], the technique of microwestern array was applied. An ‘X’ entry in this table signifies that a time course of phosphorylation for the indicated residue was measured in the indicated study.