From: Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise
d M A P 3 K d t
v 2 â v 1
d p M A P 3 K d t
v 1 - v 2
d M A P 2 K d t
v 6 â v 3
d p M A P 2 K d t
v 3 + v 5 â ( v 4 + v 6 )
d p p M A P 2 K d t
v 4 â v 5
d M A P K d t
v 10 â v 7
d p M A P K d t
v 7 + v 9 â ( v 8 + v 10 )
d p p M A P K d t
v 8 â v 9
d R a s G T P d t
K 1 Ï 1 exp â t Ï 1 + K 2 Ï 2 exp â t Ï 2 ; R a s G T P t = K 1 1 â e â t / Ï 1 + K 2 1 â e â t / Ï 2