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Table 2 Ordinary differential equations for the ERK signaling cascade model

From: Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

d M A P 3 K d t v 2 v 1
d p M A P 3 K d t v 1 - v 2
d M A P 2 K d t v 6 v 3
d p M A P 2 K d t v 3 + v 5 ( v 4 + v 6 )
d p p M A P 2 K d t v 4 v 5
d M A P K d t v 10 v 7
d p M A P K d t v 7 + v 9 ( v 8 + v 10 )
d p p M A P K d t v 8 v 9
d R a s G T P d t K 1 τ 1 exp t τ 1 + K 2 τ 2 exp t τ 2 ; R a s G T P t = K 1 1 e t / τ 1 + K 2 1 e t / τ 2
  1. K’s and τ’s are determined as described in Methods.