Figure 4

Simulations and lab results experiment #25. A: Reprint of figure 4B in [22] (License agreement number 2838800627526): NIH 3T3 cells were co-transfected with the luciferase reporter under the control of the mMCP6 promoter, MITF, PIAS3, and STAT3 mutants (STAT3-C and Y705F-STAT3). B: Simulation of the same experiment (Experiment 25 in Table 2). The white bars in the reprint and the blue bars in the simulation results represent the MITF activity in cells transfected with only STAT3, the grey bars in the reprint and the green bars in the simulation results represent the MITF activity in cells transfected with STAT3 and MITF, and the black bars in the reprint and the red bars in the simulation results represents the MITF activity in cells transfected with STAT3, MITF and PIAS3.