From: Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection
Description | Reference | |
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1. | Temporal development of ERK and RSK1 kinase activity | [14]Figure 5B |
2. | Distribution between MITF phosphorylation before stimulation | [14]Figure 1 and 2 |
3. | Temporal development of MITF phosphorylation states after stimulation | [14]Figure 1 and 2 |
4. | Temporal development of MITF degradation | [14]Figure 1 and 2 |
5. | MITF activity in response to PIAS3 transfection | [19]Figure 6 |
6. | Amount of MITF-PIAS3 complex in response to activation | [20] Figure 2A |
7. | Amount of MITF-PIAS3 complex in response to activation with transfected MITF and PIAS3 | [20] Figure 2B |
8. | MITF activity in response to transfection of constitutively active RSK1 | [20] Figure 3A |
9. | MITF activity in response to PIAS3 | [20] Figure 3B, left, black |
10. | MITF activity in response to transfection of PIAS3 and active RSK1 | [20] Figure 3B, left, grey |
11. | Activity of a MITF-S409A mutant in response to PIAS3 | [20] Figure 3B, right, black |
12. | Activity of a MITF-S409A mutant in response to transfection of PIAS3 and active RSK1 | [20] Figure 3B, right, grey |
13. | Activity of MITF in response to transfection of PIAS3 | [20] Figure 6 |
14. | Activity of MITF-S73D mutant in response to transfection of PIAS3 | [20] Figure 6 |
15. | Activity of MITF-S409D mutant in response to transfection of PIAS3 | [20] Figure 6 |
16. | Activity of MITF-S73/409D mutant in response to transfection of PIAS3 | [20] Figure 6 |
17. | MITF-PIAS3 association in response to activation | [22] Figure 3A |
18. | S409A mutated MITF-PIAS3 association in response to activation | [22] Figure 3A |
19. | STAT3 activity in response to activation | [22] Figure 3B |
20. | STAT3 activity in response to activation with transfected PIAS3 | [22] Figure 3B |
21. | STAT3 activity in response to activation with transfected PIAS3 and small amount of MITF | [22] Figure 3B |
22. | STAT3 activity in response to activation with transfected PIAS3 and large amount of MITF | [22] Figure 3B |
23. | STAT3 activity in response to activation with transfected PIAS3 and small amount of S-409A mutated MITF | [22] Figure 3B |
24. | STAT3 activity in response to activation with transfected PIAS3 and large amount of S409A mutated MITF | [22] Figure 3B |
25. | MITF activity in response to transfection of Y705F mutated STAT3 and STAT3-C | [22] Figure 4B |
26. | MITF and STAT3 activity in response to activation compared between wild type and mutated MITF (unable to bind PIAS3) | [22] Figure 6D and E |
27. | STAT3 activity in response to transfection of MITF or S409D MITF mutation | [22] Figure 7C |
28. | MITF activity in response to transfection of STAT3-C | [22] Figure 7D |