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Figure 1 | BMC Systems Biology

Figure 1

From: CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism

Figure 1

Illustration of total substrate uptake rate ( v s ) and oxygen demand ( v O 2 ) for a fixed glucose supply with (A) β = 0.25 and (B) β = 0.75. The ATP consumption rate (vATPase) were restricted to 21.6[ mmol min · ( l cell ) ]. The panels A.1 and B.1 refer to the oxygen demand ( v O 2 ) for the given glucose proportion, while panels A.2 and B.2 refer to the total substrate uptake rate (v s ). For each panel we marked the optimal substrate composition (*): (A) v Glucose = 25%, v Oleate = 64%, v Acetoacetate = 0%, v Lactate = 11%, (B) v Glucose = 75%, v Oleate = 25%, v Acetoacetate = 0%, v Lactate = 0%.

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