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Table 4 Simulation of experimental substrate supply and comparison by calculated efficiency C i +

From: CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism

     Simulation   Experiment
Exp. Substrate β m   v O 2 vs v O 2 / v s C i +   v O 2 vs v O 2 / v s C i +
     [ mmol min · ( l cell ) ] [ mmol min · ( l cell ) ]     [ mmol min ] [ mmol min ]   
1 Glucose 1.00   3.60 0.60 6.00 0.83   4.28 0.55 7.84 0.78
2.1 Lactate 1.00   3.81 1.17 3.25 0.60   4.71 1.41 3.34 0.21
2.2 Glucose 0.23   3.73 0.96 3.89 0.69   4.70 1.59 2.96 0.15
  Lactate 0.77           
3.1 Oleate 1.00   4.11 0.16 25.37 0.82   4.94 0.18 28.07 0.67
3.2 Glucose 0.54   4.02 0.24 16.75 0.85   4.36 0.21 20.57 0.91
  Oleate 0.46           
4.1 Acetate 1.00   4.8 2.4 2 0   4.28 1.68 2.55 0.31
4.2 Glucose 0.05   4.6 2.11 2.19 0.14   4.69 1.46 3.21 0.2
  Acetate 0.95           
5.1 Acetoacetate 1.00   3.93 0.98 4.00 0.65   4.20 0.53 7.89 0.59
5.2 Glucose 0.26   3.81 0.86 4.41 0.71   4.95 1.01 4.91 0.37
  Acetoacetate 0.74           
  1. v O 2 indicates oxygen demand;vs, total substrate uptake rate; C i + , calculated efficiency.