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Figure 11 | BMC Systems Biology

Figure 11

From: Continuous time boolean modeling for biological signaling: application of Gillespie algorithm

Figure 11

MaBoSS outputs of the model of the mammalian cell cycle: stationary distributions. BKMC algorithm is applied to the mammalian cell cycle model, with random initial conditions. Results of the clustering algorithm that associates a cluster to each indecomposable stationary distribution. (a) Probability of reaching each identified cluster; these probabilities are estimated by the proportion of trajectories that belong to each cluster. (b) First estimated cluster that can be interpreted as a desynchronized population of cells that are dividing. (c) Second estimated cluster, corresponding to a fixed point, that can be interpreted as a G1 cell cycle arrest with no growth factors.

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