Figure 1

CA04 differentially expressed genes. The transcription profiles of select DE genes on day 3 (top) and day 7 p.i (bottom). Each column represents the gene expression profile of an individual macaque lung tissue sample; gene expression levels for two samples acquired from a uninfected animal are also shown (to the left) for reference. The lesion severity, as described in (11), for each sample is shown at the bottom (Damage) of each heat map. White indicates no lesions; blue represents lung lesions with severe alveolar wall thickening; yellow indicates mild lung lesions with some antigen-positive cells present; orange indicates severe lesions containing a significant number of virus antigen-positive cells; and red indicates severe lung lesions in which the alveolar space was filled with inflammatory cells.