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Figure 4 | BMC Systems Biology

Figure 4

From: Integrated network analysis reveals a novel role for the cell cycle in 2009 pandemic influenza virus-induced inflammation in macaque lungs

Figure 4

Protein-protein interaction subnetworks differentially regulated in CA04-infected lung tissue. IPA was used to determine subnetworks within the human PPI which were highly populated with genes differentially expressed in CA04-infected tissue on day 7 p.i. We show the top networks (based on their network score) when (A) up to 70 proteins are allowed in the subnetwork and (B-D) the top 3 networks when the size of the subnetwork is limited to 35 proteins. Each network is labeled according to its most enriched biological function. Proteins that’s transcript is up-regulated or down-regulated in CA04-infected lung relative to KUTK4-infected lung are colored red and green, respectively. Additional file 9 provides a larger illustration of panel A with all protein labels shown.

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BMC Systems Biology

ISSN: 1752-0509

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