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Figure 5 | BMC Systems Biology

Figure 5

From: Integrated network analysis reveals a novel role for the cell cycle in 2009 pandemic influenza virus-induced inflammation in macaque lungs

Figure 5

Differential response network between CA04- and KUTK4-infected lung tissue. Highly enriched canonical pathways identified by using IPA (namely, ‘Role of CHK Proteins in Cell Cycle Checkpoint Control’, enclosed by the white, broken line and ‘Role of Cytokines in Mediating Communication between Immune Cells’, enclosed by the blue broken line) were integrated by using highly enriched transcription factors and IPA's Expert Curated protein-protein interaction database. Newly identified interactions which are not part of the canonical pathways are illustrated with red arrows, whereas interactions belonging to the canonical pathways are colored black. Proteins that are differentially up-regulated in CA04-infected lung tissue relative to KUTK4-infected lung tissue on day 7 p.i. are colored red. Three chemokines and one chemokine receptor which were up-regulated in the CA04 infection on day 3 as well are demarcated by red stars adjacent the protein. Transcription factors or cell types for which the transcription factors surrogate as cell markers are boxed in red or black representing enrichment on day 3 or day 7 p.i., respectively.

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