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Figure 1 | BMC Systems Biology

Figure 1

From: Regulation of cytoplasmic polyadenylation can generate a bistable switch

Figure 1

The simplified model of CPEB1 mediated polyadenylation of αCaMKII through a self-sustaining αCaMKII-CPEB 1 molecular loop. The αCaMKII, molecule can be inactive, or active and phosphorylated state, while CPEB1 can be in unphosphorylated and phosphorylated states. The αCaMKII molecule in both these states degrades with a certain degradation rate. The active and phosphorylated CaMKII phosphorylate the CPEB1 molecule, which through polyadenylation of αCaMKII mRNA generates the new CaMKII molecule. Here, the synthesis of new αCaMKII molecule is represented by a translation step (T) which, describe the multi-step translation process through a single biochemical reaction R6 as described in appendix.

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