Skip to main content

Advertisement

Figure 3 | BMC Systems Biology

Figure 3

From: Regulation of cytoplasmic polyadenylation can generate a bistable switch

Figure 3

The dynamic characteristics of aCaMKII-CPEB 1 molecular loop. These characteristics are developed through three alternative models. First model is based on differential equations A1-A6 (Full model, represented by solid red line (up state) and solid blue line (down state)). Second model is based on differential equation 1, B-6 and B-9 (Reduced model, represented by dotted red line (up state) and dotted blue line (down state)). Third model is based only on a single differential equation (equation 6) (Single differential equation model, represented by dotted black line (up state) and dotted blue line (down state)). System moves from down to up-regulated state through a 10 second application of (Ca+2 )4-CaM pulse. The dynamic simulations are carried out with two different set of parameters. For one set of parameters the dynamic from three alternative models converge to same upper and lower steady states (a). In this case the dynamics converge to same upper steady state at XT = 95 and lower steady state at XT = 0.0 For second selection of parameters the dynamic results from three alternative models does not converge to same upper steady state (b) although the lower steady state remains the same for all three models. Here, the dynamics from full model converge to upper steady state at XT = 360 and lower state at XT = 0.0001 (Figure 3 b, solid red line (up state) and solid blue line (down state)), whereas the dynamics from reduced model (dotted red line (up state) and dotted blue line (down state)) and single differential equation model (dotted black line (up state) and dotted blue line (down state)) converge to upper steady state at XT = 95 and lower state at XT = 0.0001.

Back to article page