Figure 3
From: Computational modeling of apoptotic signaling pathways induced by cisplatin
Simulated results of the variables related to the mitochondrial pathway by DNA damage. (A) Cisplatin induces DNA damage. (B) DNA damage activates ATR and p53. ATR*_p53, binding of ATR* and p53. (C) P53 then induces activation of caspase-2. p53*_Casp2, binding of p53* and casp2, (D) leading to AIF release from mitochondria and subsequent caspase-independent apoptosis. AIFmit, AIF in mitochondria; AIF, leaked AIF in the cytosol. (E, F) On the other hand, apoptosis induced by p53 binding with Bax is dependent on Bax/Bak, which induces cytochrome c release. Cyt.c, leaked cytochrome c in the cytosol; p53*_Bax, binding of p53* and Bax; Bax_Bak, binding of Bax and Bak.