Figure 4
From: Computational modeling of apoptotic signaling pathways induced by cisplatin
Simulated results of the variables related to the mitochondrial pathway by oxidative stress. (A) Increased ROS in mitochondria by cisplatin induces MPTP. Aqcis, aquated cisplatin; mitROS, increased ROS in mitochondria; mitPTP*, opened mitochondrial permeability transition pore. (B) MPTP induces cytochrome c release, which activates caspase-9. Cyt.c, cytochrome c in cytosol; Cyt.cmit, cytochrome c in mitochondria; Cyt.c _Casp9, binding of Cyt.c and Casp9. (C, D) IAP inhibits activated caspase-9 and −3, which induce apoptosis. Casp9*_IAP, binding of Casp9* and IAP; Casp3*_IAP, binding of Casp3* and IAP; Casp9*_Casp3, binding of Casp9* and Casp3. Activated caspase-9 subsequently initiates caspase-3 activation (D) and induces apoptosis (E).