Figure 5
From: Computational modeling of apoptotic signaling pathways induced by cisplatin
Interaction between apoptosis and AIF, p53 activation, IAP, Bcl-2, or Cyt. c . (A) Interaction between apoptosis and p53* or IAP. Inhibition of p53 and AIF shows a decrease in apoptosis.  × 1.0, baseline value; p53*  × 0.3, activated p53 decrease by thirtyfold; AIF  ×  0.1, AIF decrease by tenfold. (B) Interaction between Casp3* and IAP without IAP, IAP  = 0; with IAP, IAP at baseline value; IAP  × 0.2, IAP decrease by twentyfold. (C) Interaction between apoptosis and IAP. Bcl-2 impairs activation of Bax/Bak. (D) Interaction between Bax_Bak and Bcl-2. Bcl-2  × 1.0, Bcl-2 at baseline value; Bcl-2  × 0.1, Bcl-2 decrease by tenfold; Bcl-2  × 10.0, Bcl-2 increase by tenfold. (E) Interaction between apoptosis and Cyt.c. with Cyt.c, Cyt.c at baseline value; Cyt.c  ×  5.0, Cyt.c increase by fivefold; Cyt.c  ×  0.2, Cyt.c decrease by fivefold. (F) Interaction between apoptosis and Bcl-2 without Bcl-2, Bcl-2  = 0; with Bcl-2, Bcl-2 at baseline value; Bcl-2  × 0.2, IAP decrease by twentyfold.