Table 7 Effects of parameters on apoptosis
From: Computational modeling of apoptotic signaling pathways induced by cisplatin
Selected parameters (Higher sensitive parameters in sensitivity analysis) | +30% parameter value | −30% parameter value | ||
|---|---|---|---|---|
| Â | Parameter range | Apoptosis level (0.22512) | Parameter range | Apoptosis level (0.22512) |
k1+ = 1 μM-1 s-1 | k1+ = 1.3 | 0.24831 (+10.3%) | k1+ = 0.7 | 0.19202 (−14.7%) |
k13+ = 5 μM-1 s-1 | k13+ = 6.5 | 0.19674 (−12.6%) | k13+ = 3.5 | 0.27136 (+20.54%) |
k14+ = 0.5 μM-1 s-1 | k14+ = 0.65 | 0.23067 (+2.46%) | k14+ = 0.35 | 0.2172 (−3.52%) |
k15+ = 0.5 μM-1 s-1 | k15+ = 0.65 | 0.23067 (+2.46%) | k15+ = 0.35 | 0.2172 (−3.52%) |
k29+ = 0.5 μM-1 s-1 | k29+ = 0.65 | 0.22952 (+1.95%) | k29+ = 0.35 | 0.21911 (−2.66%) |
k30+ = 0.5 μM-1 s-1 | k30+ = 0.65 | 0.22952 (+1.95%) | k30+ = 0.35 | 0.21911 (−2.66%) |
k31+ = 1 μM-1 s-1 | k31+ = 1.3 | 0.22952 (+1.95%) | k31+ = 0.7 | 0.21911 (−2.66%) |
k32+ = 0.5 μM-1 s-1 | k32+ = 0.65 | 0.23424 (+4.05%) | k32+ = 0.35 | 0.20999 (−6.72%) |
k33+ = 1 μM-1 s-1 | k33+ = 1.3 | 0.232 (+3.05%) | k33+ = 0.7 | 0.21389 (−4.98%) |
k34+ = 1 s-1 | k34+ = 1.3 | 0.2392 (+6.25%) | k34+ = 0.7 | 0.19967 (−11.3%) |
k36+ = 1 s-1 | k36+ = 1.3 | 0.238 (+5.72%) | k36+ = 0.7 | 0.20434 (−9.23%) |