Figure 3

mRNA and protein correlation and GO based modeling of 88 concordantly expressed host gene products. Overall correlation (R² = 0.0007) of protein and mRNA fold changes in CD30^hi, compared to CD30^lo lymphocytes ((A); n = 4592). Overall correlation for gene products differentially expressed in the same direction at both mRNA and protein levels showing higher correlation (n = 88, R² = 0.5581). The triangles indicate genes known to be involved in CD30^hi lymphomas, and have mRNA: protein correlation close to 1 (R² = 0.92). CST3 is also involved in in CD30^hi lymphomas but has very low mRNA: protein correlation. (B). Gene Ontology (GO) Biological Processes (BP) associated with the concordantly-expressed gene products indicates involvement in cellular processes perturbed in neoplastic transformation (C). Concordant gene products were ranked based mRNA: protein correlation and then grouped into pentiles and distribution of GO BP by pentile were compared. Cell cycle and proliferation are disproportionately represented in pentile 1 (D-i). Pentile 1 genes have more putative Meq binding sites in their promoters than genes in the other pentiles (mean ± sem) (D-ii).