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Table 1 The results of the ErbB pathway analysis

From: A simple knowledge-based mining method for exploring hidden key molecules in a human biomolecular network

Gene symbol

Degree

nlBC

Included in

the input

Simulated

p-value

EGFR

129

0.248

no

5. 01×10−5

JUN

90

0.0854

yes

1. 17×10−3

CREBBP

124

0.0919

no

1. 42×10−3

TCF3

24

0.0431

no

1. 59×10−3

FOXO4

9

0.00429

no

2. 62×10−3

EP300

146

0.102

no

2. 70×10−3

ERBB2

33

0.0274

no

6. 05×10−3

CDC25A

18

0.0149

no

8. 28×10−3

CABIN1

8

0.0369

no

9. 42×10−3

ERBB3

13

0.0329

no

9. 76×10−3

TFDP2

4

0.0039

no

1. 12×10−2

CEBPB

34

0.0261

no

1. 18×10−2

BAG1

13

0.00881

no

1. 19×10−2

ID2

17

0.0318

no

1. 28×10−2

MEF2D

11

0.00573

yes

1. 34×10−2

MYBL2

13

0.0445

no

1. 44×10−2

ERBB4

19

0.0304

no

1. 74×10−2

SP1

59

0.0288

no

1. 92×10−2

RB1

92

0.061

no

2. 02×10−2

HCFC1

26

0.0352

no

2. 11×10−2

RYBP

13

0.0155

no

2. 12×10−2

E2F4

21

0.00537

yes

2. 31×10−2

USP7

42

0.0606

no

2. 41×10−2

SRF

26

0.0427

no

2. 85×10−2

TFDP1

14

0.00927

no

2. 96×10−2

RBL2

25

0.00674

no

3. 01×10−2

STAT1

50

0.026

yes

3. 06×10−2

E2F1

45

0.0282

yes

3. 31×10−2

ATF2

27

0.00428

no

4. 78×10−2

CEBPA

21

0.00393

no

4. 89×10−2

YWHAQ

63

0.0189

no

4. 93×10−2

  1. Key molecules (genes) with simulated p-values less than 0.05 are listed in the order of ascending p-values. The degree is the number of edges (number of interaction partners), and the fourth column indicates whether the gene was included in the input list of genes.