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Table 1 The results of the ErbB pathway analysis

From: A simple knowledge-based mining method for exploring hidden key molecules in a human biomolecular network

Gene symbol Degree nlBC Included in
the input
Simulated
p-value
EGFR 129 0.248 no 5. 01×10−5
JUN 90 0.0854 yes 1. 17×10−3
CREBBP 124 0.0919 no 1. 42×10−3
TCF3 24 0.0431 no 1. 59×10−3
FOXO4 9 0.00429 no 2. 62×10−3
EP300 146 0.102 no 2. 70×10−3
ERBB2 33 0.0274 no 6. 05×10−3
CDC25A 18 0.0149 no 8. 28×10−3
CABIN1 8 0.0369 no 9. 42×10−3
ERBB3 13 0.0329 no 9. 76×10−3
TFDP2 4 0.0039 no 1. 12×10−2
CEBPB 34 0.0261 no 1. 18×10−2
BAG1 13 0.00881 no 1. 19×10−2
ID2 17 0.0318 no 1. 28×10−2
MEF2D 11 0.00573 yes 1. 34×10−2
MYBL2 13 0.0445 no 1. 44×10−2
ERBB4 19 0.0304 no 1. 74×10−2
SP1 59 0.0288 no 1. 92×10−2
RB1 92 0.061 no 2. 02×10−2
HCFC1 26 0.0352 no 2. 11×10−2
RYBP 13 0.0155 no 2. 12×10−2
E2F4 21 0.00537 yes 2. 31×10−2
USP7 42 0.0606 no 2. 41×10−2
SRF 26 0.0427 no 2. 85×10−2
TFDP1 14 0.00927 no 2. 96×10−2
RBL2 25 0.00674 no 3. 01×10−2
STAT1 50 0.026 yes 3. 06×10−2
E2F1 45 0.0282 yes 3. 31×10−2
ATF2 27 0.00428 no 4. 78×10−2
CEBPA 21 0.00393 no 4. 89×10−2
YWHAQ 63 0.0189 no 4. 93×10−2
  1. Key molecules (genes) with simulated p-values less than 0.05 are listed in the order of ascending p-values. The degree is the number of edges (number of interaction partners), and the fourth column indicates whether the gene was included in the input list of genes.