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Figure 4 | BMC Systems Biology

Figure 4

From: Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention

Figure 4

Dependence of the network dynamics on p53 and NF-κB. A-E: Interaction graphs of the core network comprising only the regulatory components ‘DSBs early‘, DSBs late‘, ‘RPA-P-ATR-ATRIP-P‘, ‘ATM-P‘, p53-P‘, and ‘nuclear p50-p65-P‘. Shown are the networks for the wildtype (A), the mutant with constitutively active p50-p65-P (B), p53-deficiency (C), both constitutively active p50-p65-P and p53-deficiency (D), and constitutively active p53 (E). a-e: corresponding state transition graphs, which illustrate the dynamical behaviour of the networks. The nodes of the state transition graphs gives the activity levels of ‘DSBs early‘ (first digit), ‘DSBs late‘ (second digit), ‘RPA-P-ATR-ATRIP-P‘,(third digit), ‘ATM-P‘ (fourth digit), p53-P‘ (fifth digit), and ‘nuclear p50-p65-P‘ (sixth digit). State transition graphs a-c show only attractors. In d and e, complete state transition graphs are given, wherein the logical steady states are marked with ellipses.

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BMC Systems Biology

ISSN: 1752-0509

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