A checkpoints capturing timing-robust Boolean model of the budding yeast cell cycle regulatory network

Table 6 Fraction of timing-robust mutants for each phase

Phase	Mutation	Li, et al.	Mangla, et al.	Proposed
	distance	% of timing-robust	% of timing-robust	% of timing-robust
	1	0.00	0.31	0.31
G1	2	0.00	0.22	0.22
	3	0.00	0.15	0.15
	1	0.00	0.26	0.22
S	2	0.00	0.12	0.20
	3	0.00	0.07	0.10
	1	0.00	0.17	0.27
G2	2	0.00	0.09	0.21
	3	0.00	0.08	0.12
	1	0.00	0.22	0.28
M	2	0.00	0.14	0.16
	3	0.00	0.13	0.13

The second column represents the number of mutations applied to a model. To perturb only an interested cell cycle phase, we applied mutations to edges related to the corresponding phase by deleting, adding, or re-weighting them. In this way, 200 mutant networks were generated, and then checked whether they preserve the desired attractor, the G1 stationary state under the asynchronous update rule using NuSMV. Columns from third to fifth represent the fraction of timing-robust mutants in each model.