From: A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation
Dietary Species | Symbol | Initial Value |
---|---|---|
Dietary cholesterol | DC | 304 mg |
Intestinal Species | Â | Â |
Intestinal cholesterol | IC | 3150 mg |
Intestinal bile salts | IBS | 467 mg |
Intestinal cholesterol synthesis | ICS | 0 (Source Species) |
Intestinal nascent high density lipoprotein synthesis | INHDLS | 0 (Source species) |
Excreted Species | Â | Â |
Excreted cholesterol | EC | 0 |
Excreted bile salts | EBS | 0 |
Hepatic Tissue Species | Â | Â |
Hepatic cholesterol synthesis | HCS | 0 (Source Species) |
Hepatic nascent HDL synthesis | HNHDLS | 0 (Source Species) |
Hepatic bile salt pool | HBS | 400 mg |
Hepatic free cholesterol | HFC | 60000 mg |
Hepatic low density lipoprotein receptors | HLDLRs | 100 (Theoretical value to represent the number of hepatic LDL receptors ) |
Hepatic low density lipoprotein receptor synthesis | HLDLRsS | 600 (Source species) |
Hepatic LDL receptors degradation | HLDLRD | 0 (Sink species) |
Hepatic cholesterol esters | HCE | 10000 mg |
Scavenger receptor class B type 1 | SRB1 | 100 (Theoretical value to represent concentration of SRB1 receptors) |
Peripheral Tissue Species | Â | Â |
Peripheral low density lipoprotein receptors | PLDLRs | 100 (Theoretical value) |
Peripheral low density lipoprotein receptors synthesis | PLDLRsS | 575.16 (Source species) |
Peripheral low density lipoprotein receptors degradation | PLDLRD | 0 (Sink species) |
Peripheral free Cholesterol | PFC | 57516 mg |
Peripheral cholesterol esters | PCE | 9363 mg |
Peripheral steroid synthesis | PSS | 0 (Sink species) |
Peripheral cholesterol synthesis | PCS | 0(Source species) |
Plasma Species | Â | Â |
Low density lipoprotein cholesterol | LDLC | 100 mg/dL |
High density lipoprotein cholesterol | HDLC | 45 mg/dL |
Nascent high density lipoprotein | NHDL | 100 (Theoretical value to represent the initial number of Nascent HDL) |
Very low density lipoprotein cholesterol | VLDLC | 20 mg/dL |
Intermediate density lipoprotein cholesterol | IDLC | 20 mg/dL |
Cholesteryl ester transfer protein | CETP | 100 (Fixed boundary condition) |
Lecithin:cholesterol acyltransferase | LCAT | 100 (Fixed boundary condition) |
Hormone sensitive Lipase | HSL | 100 (Fixed boundary condition) |
Lipoprotein Lipase | LPL | 100 (Fixed boundary condition) |
Hepatic Tissue Species and Peripheral Tissue | ||
Species | Â | Â |
Cholesterol ester hydrolase | CEH | 100 (Fixed boundary condition) |
acyl coenzyme A: cholesterol acyltransferase | ACAT | 100 (Fixed boundary condition) |