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Table 1 List of species, their abbreviations and their initial values

From: A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation

Dietary Species

Symbol

Initial Value

Dietary cholesterol

DC

304 mg

Intestinal Species

  

Intestinal cholesterol

IC

3150 mg

Intestinal bile salts

IBS

467 mg

Intestinal cholesterol synthesis

ICS

0 (Source Species)

Intestinal nascent high density lipoprotein synthesis

INHDLS

0 (Source species)

Excreted Species

  

Excreted cholesterol

EC

0

Excreted bile salts

EBS

0

Hepatic Tissue Species

  

Hepatic cholesterol synthesis

HCS

0 (Source Species)

Hepatic nascent HDL synthesis

HNHDLS

0 (Source Species)

Hepatic bile salt pool

HBS

400 mg

Hepatic free cholesterol

HFC

60000 mg

Hepatic low density lipoprotein receptors

HLDLRs

100 (Theoretical value to represent the number of hepatic LDL receptors )

Hepatic low density lipoprotein receptor synthesis

HLDLRsS

600 (Source species)

Hepatic LDL receptors degradation

HLDLRD

0 (Sink species)

Hepatic cholesterol esters

HCE

10000 mg

Scavenger receptor class B type 1

SRB1

100 (Theoretical value to represent concentration of SRB1 receptors)

Peripheral Tissue Species

  

Peripheral low density lipoprotein receptors

PLDLRs

100 (Theoretical value)

Peripheral low density lipoprotein receptors synthesis

PLDLRsS

575.16 (Source species)

Peripheral low density lipoprotein receptors degradation

PLDLRD

0 (Sink species)

Peripheral free Cholesterol

PFC

57516 mg

Peripheral cholesterol esters

PCE

9363 mg

Peripheral steroid synthesis

PSS

0 (Sink species)

Peripheral cholesterol synthesis

PCS

0(Source species)

Plasma Species

  

Low density lipoprotein cholesterol

LDLC

100 mg/dL

High density lipoprotein cholesterol

HDLC

45 mg/dL

Nascent high density lipoprotein

NHDL

100 (Theoretical value to represent the initial number of Nascent HDL)

Very low density lipoprotein cholesterol

VLDLC

20 mg/dL

Intermediate density lipoprotein cholesterol

IDLC

20 mg/dL

Cholesteryl ester transfer protein

CETP

100 (Fixed boundary condition)

Lecithin:cholesterol acyltransferase

LCAT

100 (Fixed boundary condition)

Hormone sensitive Lipase

HSL

100 (Fixed boundary condition)

Lipoprotein Lipase

LPL

100 (Fixed boundary condition)

Hepatic Tissue Species and Peripheral Tissue

Species

  

Cholesterol ester hydrolase

CEH

100 (Fixed boundary condition)

acyl coenzyme A: cholesterol acyltransferase

ACAT

100 (Fixed boundary condition)