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Figure 1 | BMC Systems Biology

Figure 1

From: Gene autoregulation via intronic microRNAs and its functions

Figure 1

Representation of iMSL and the two circuits used for comparison. Schematic views of (A) an intronic miRNA-mediated self-loop (iMSL); (B) a gene simply activated by a TF (sTF); (C) a transcriptional self-regulation (tSL). A more detailed representation of the three circuits is on the right of the figure. Green rectangles are DNA-genes; s and r are the transcribed miRNAs and mRNAs (orange and red stars respectively) which can eventually be degraded (broken grey stars). mRNAs can be translated into proteins p (blue circles) and proteins can be degraded (broken grey circles). The reaction rates are reported along the corresponding black arrows: k r (q) and k r (q,p) for transcription; k p (s), kp 2 and k p for translation; g s , g r and g p for degradation. Red arrows represent activations, while red lines ending in bars are repressions. For the iMSL and the sTF, the transcription rates are functions of the amount of TFs q, while for the tSL the transcription rate is also a function of the target protein p. In the iMSL, miRNA regulation makes the rate of translation a function of the amount of miRNAs s.

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