Figure 2

Perturbation analysis of a gene in the SCC Perturbation of the TLR2 gene (black diamond), and its effect on the other genes of the SCC. Y-axis: 0 indicates the “off” state, 1 indicates the “on” state. TLR2 is capable of triggering the transition from the “off” (healthy) to the “on” (disease) stable state for all genes in the SCC. The simulations were performed assuming a continuous dynamical system where the initial states are the attractors previously computed in a discrete model (Boolean). The Y-axis represents the “level of activity” in a range between 0 and 1, and X-axis represents “time” in arbitrary units.