Table 1 Summary of the genes and their functional categories
Biological function | Â | Genesa |
|---|---|---|
Prp(Sc replication and accumulation | Â | A2M, ABCA1, ADAMTS1, APOD, PTGS1, SERPING1 |
Immune response | Â | Â |
| Â | Complement activation: complement system | C3 |
| Â | Complement activation: coagulation & kallikrein system | PDPN, PROS1 |
| Â | Pattern recognition and other receptor | CD14, CD68, ITGB2, FCGR2B, TREM2, TLR2 |
| Â | Microglia/astrocyte activation related | GFAP, PTPN6, STAT1, STAT3, THBS2, TNFRSF1A, VIM |
| Â | Cytokine, chemokine and growth factor related | CSF1, CSF1R, CXCL10, CX3CR 1 |
| Â | Leukocyte extravasation | CYBB, ITGAX, NCF1, TGFB1, TGFBR1, TGFBR2 |
| Â | Other immune response | AIF1, B2M, CD83, CD86, CEBPA, CEBPD, Ctla2a, HLA-E, IFI27, IFIT3, NFATC1, SBNO2 |
Cell death | Â | CASP1, CCN D1, CLU, HSPB1, HSPB8, ID3, MCL1, RBP1, SOCS3, TGM2 |
Other | Â | ALOX5AP, CD9, FLI1, GUSB, HPGD, IL13RA1, INPP5D, ISG15, LCN2, LGAL53, LXN, MET, OSMR, P2RX7, S100A4, SOX9, SRGN, SYNPO, TF |