TY - JOUR AU - Karelina, Tatiana A. AU - Zhudenkov, Kirill V. AU - Demin, Oleg O. AU - Svetlichny, Dmitry V. AU - Agoram, Balaji AU - Fairman, David AU - Demin, Oleg V. PY - 2012 DA - 2012/11/12 TI - Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach JO - BMC Systems Biology SP - 141 VL - 6 IS - 1 AB - 5-lipoxygenase (5-LO) is a key enzyme in the synthesis of leukotrienes and 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (oxoETE). These inflammatory signaling molecules play a role in the pathology of asthma and so 5-LO inhibition is a promising target for asthma therapy. The 5-LO redox inhibitor zileuton (Zyflo IR/CR®) is currently marketed for the treatment of asthma in adults and children, but widespread use of zileuton is limited by its efficacy/safety profile, potentially related to its redox characteristics. Thus, a quantitative, mechanistic description of its functioning may be useful for development of improved anti-inflammatory targeting this mechanism. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-6-141 DO - 10.1186/1752-0509-6-141 ID - Karelina2012 ER -