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Table 2 Potency of 5-LO Inhibitors in “LOS” model at different peroxide concentrations

From: Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach

Peroxide concentration (μM) IC50 for inhibition by Zileuton (nM) IC50 for inhibition by PF-4191834(nM)
For LTA4 For 5oxoETE For LTA4 For 5oxoETE
0 980 962 122 125
5* 860 1145 125 129
10** 860 1410 143 146
100 1450 12670 290 300
  1. *- corresponds to healthy subjects.
  2. ** - corresponds to asthmatic subjects.