From: Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach
Peroxide concentration (μM)
IC50 for inhibition by Zileuton (nM)
IC50 for inhibition by PF-4191834(nM)
For LTA4
For 5oxoETE
0
980
962
122
125
5*
860
1145
129
10**
1410
143
146
100
1450
12670
290
300