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Table 2 Potency of 5-LO Inhibitors in “LOS” model at different peroxide concentrations

From: Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach

Peroxide concentration (μM)

IC50 for inhibition by Zileuton (nM)

IC50 for inhibition by PF-4191834(nM)

For LTA4

For 5oxoETE

For LTA4

For 5oxoETE

0

980

962

122

125

5*

860

1145

125

129

10**

860

1410

143

146

100

1450

12670

290

300

  1. *- corresponds to healthy subjects.
  2. ** - corresponds to asthmatic subjects.