Figure 5

Predicted change in metabolic pathway activity following temperature change. GX-FBA predicted change in activity of select pathways in Y. pestis biovar Mediaevalis in response to change in temperature from 26°C to 37°C: a) for strains 201 under LCR conditions and b) for strain KIM5 in a Ca²⁺ rich environment. Blue=flux decrease, red=flux increase, green=flux did not increase or decrease by at least a factor of 2. The graph is made using the iPath2 program [70] and the width of the lines (w) is set to: $w=20+{log}_{10}\left(\frac{{\nu }_i^{\mathit{GX}-\mathit{FBA}}}{{\nu }_i^{\mathit{wt}}}\right)$. If calculated w<0 for sake of being able to notice the change w=1.