Table 1 Main enriched signaling pathways of torcetrapib related to its adverse reactions (FDR<0.05)
Index | Driving genes | Pathways | p-value |
|---|---|---|---|
GRN1 | CBL,SOCS1 | BioCarta: IL-2 Receptor Beta Chain in T cell Activation | 4.112E-18 |
CBL,SOCS1 | NCI-Nature Curated: PDGFR-beta signaling pathway | 5.309E-12 | |
SOCS1 | NCI-Nature Curated: IL2-mediated signaling events | 1.491E-10 | |
CBL | KEGG pathway: ErbB signaling pathway | 1.838E-10 | |
GRN2 | JUN | NCI-Nature Curated: Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | 1.175E-4 |
GRN3 | EXOSC6 | Reactome: Genes involved in mRNA Decay by 3’ to 5’ Exoribonuclease | 4.537E-14 |
EXOSC6 | Reactome: Genes involved in Metabolism of mRNA | 3.187E-8 | |
EXOSC6 | Reactome: Genes involved in Metabolism of RNA | 6.834E-6 |