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Table 1 Main enriched signaling pathways of torcetrapib related to its adverse reactions (FDR<0.05)

From: Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach

Index Driving genes Pathways p-value
GRN1 CBL,SOCS1 BioCarta: IL-2 Receptor Beta Chain in T cell Activation 4.112E-18
CBL,SOCS1 NCI-Nature Curated: PDGFR-beta signaling pathway 5.309E-12
SOCS1 NCI-Nature Curated: IL2-mediated signaling events 1.491E-10
CBL KEGG pathway: ErbB signaling pathway 1.838E-10
GRN2 JUN NCI-Nature Curated: Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 1.175E-4
GRN3 EXOSC6 Reactome: Genes involved in mRNA Decay by 3’ to 5’ Exoribonuclease 4.537E-14
EXOSC6 Reactome: Genes involved in Metabolism of mRNA 3.187E-8
EXOSC6 Reactome: Genes involved in Metabolism of RNA 6.834E-6
  1. FDR: false discovery rate.