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Figure 1 | BMC Systems Biology

Figure 1

From: Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE

Figure 1

mCADRE method overview. (A) After binarizing context-specific input data, we quantify how often a gene is expressed across samples of the same tissue; this is the ubiquity score U(g) for each gene g. (B) From ubiquity scores, we calculate the expression-based evidence E x for each gene-associated reaction. Reactions with sufficiently high E x are defined as the core reaction set and are included in the tissue-specific model. To deterministically rank non-core reactions with low to moderate expression-based evidence, we introduce a network topology metric to calculate connectivity-based evidence Ec.

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