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Table 5 Top 13 reactions over-represented in tumor tissue models versus corresponding normal tissue models

From: Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE

Reactionsa

% tumor models

% normal models

Rank sum p-value

ALOX5

72%

6%

8.6E-05

ALOX52

72%

6%

8.6E-05

EX_leuktrC4(e)

72%

6%

8.6E-05

GGT5r

72%

6%

8.6E-05

GGT6

72%

6%

8.6E-05

GLUtr

72%

6%

8.6E-05

GTHRDtr

72%

6%

8.6E-05

LEUKTRA4tr

72%

6%

8.6E-05

LEUKTRC4t

72%

6%

8.6E-05

LEUKTRD4tr

72%

6%

8.6E-05

LTC4CP

72%

6%

8.6E-05

LTC4Sr

72%

6%

8.6E-05

LTD4DP

72%

6%

8.6E-05

  1. aThese reactions form a pathway that catalyzes the production of leukotrienes from arachidonic acid.