(A) ShReD-based partition for the Day 4 flux-weighted model. (B) ShReD-based partition for the Day 12 model with LDH inhibition. The partition trees represent each module as a pie chart, where the size of each slice is proportional to the fraction of reactions in the module that belong to the corresponding, pre-assigned canonical group. The group assignments are indicated by color as shown in the legend. Modules referred to in the text are labeled with identification numbers. Reactions associated with each module are listed in Additional file2.