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Figure 1 | BMC Systems Biology

Figure 1

From: Crosstalk between transcription factors and microRNAs in human protein interaction network

Figure 1

The procedure for screening and analyzing the 4 types of regulatory motifs. The GRNs was combined from TF and miRNA regulatory relationships. According to the types of synergistic regulations between regulators, 4 types of regulatory motifs were screened, single-regulation, co-regulation, crosstalk, and independent. Then, human PINs were utilized to elucidate the significance of the correlations between these 4 types of regulatory motifs and PPIs

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