Figure 1
From: Crosstalk between transcription factors and microRNAs in human protein interaction network
The procedure for screening and analyzing the 4 types of regulatory motifs. The GRNs was combined from TF and miRNA regulatory relationships. According to the types of synergistic regulations between regulators, 4 types of regulatory motifs were screened, single-regulation, co-regulation, crosstalk, and independent. Then, human PINs were utilized to elucidate the significance of the correlations between these 4 types of regulatory motifs and PPIs