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Table 2 Z-scores of each network properties for regulatory motifs

From: Crosstalk between transcription factors and microRNAs in human protein interaction network

Motif Single-regulation Co-regulation Crosstalk
Regulator (s) TF miR TF miR TF-miR TF miR TF-miR
Degree 1.52 1.29 1.95 0.72 0.83 2.35 1.80 1.59
Closeness 1.55 1.86 2.02 1.22 1.26 2.45 2.73 2.12
Density 2.31 3.88 1.60 0.96 1.28 13.74 4.33 5.27
Clique level 1.51 1.46 1.53 1.19 1.00 2.14 2.02 1.63
Path length -15.58 -24.10 -10.25 -6.66 -7.52 -21.27 -38.25 -50.47
  1. *For single-regulation motifs, there are two types of regulators, TF and miRNA (miR). For co-regulation and crosstalk motifs, there are three types of regulators, TF-TF, miRNA-miRNA, and TF-miRNA. Here, we used TF and miR to represent TF-TF and miRNA-miRNA respectively. Path length represents the characteristic path length of the gene set.