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Table 2 Z-scores of each network properties for regulatory motifs

From: Crosstalk between transcription factors and microRNAs in human protein interaction network

Motif

Single-regulation

Co-regulation

Crosstalk

Regulator (s)

TF

miR

TF

miR

TF-miR

TF

miR

TF-miR

Degree

1.52

1.29

1.95

0.72

0.83

2.35

1.80

1.59

Closeness

1.55

1.86

2.02

1.22

1.26

2.45

2.73

2.12

Density

2.31

3.88

1.60

0.96

1.28

13.74

4.33

5.27

Clique level

1.51

1.46

1.53

1.19

1.00

2.14

2.02

1.63

Path length

-15.58

-24.10

-10.25

-6.66

-7.52

-21.27

-38.25

-50.47

  1. *For single-regulation motifs, there are two types of regulators, TF and miRNA (miR). For co-regulation and crosstalk motifs, there are three types of regulators, TF-TF, miRNA-miRNA, and TF-miRNA. Here, we used TF and miR to represent TF-TF and miRNA-miRNA respectively. Path length represents the characteristic path length of the gene set.
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BMC Systems Biology

ISSN: 1752-0509

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