Figure 2

SM-SNARE Network motif design. (a) Formulated diagram of the yeast SSNM in exocytosis. ySyx: yS25, ySyb and ySM describe Sso1p(yeast syntaxin), Sec9p(yeast SNAP25), Snc1/2p(yeast synaptobrevin) and Sec1p(SM), respectively. The logic network diagram on the left shows the cascade-like yeast SSNM. (b) Formulated diagram of neuronal network in synaptic exocytosis, nSyx, nS25, nSyb and nSM describe syntaxin-1, SNAP25, VAMP(neuronal synaptobrevin) and Munc18-1(neuronal SM), respectively. The logic network diagram on the left shows the feedback structure with modulation in the neuronal synaptic system. (c) Formulated diagram of mutant neuronal network in synaptic exocytosis, nSyx, nS25, nSyb and nSM describe syntaxin-1, SNAP25, VAMP (neuronal synaptobrevin) and Munc18-1(neuronal SM), respectively. The logic network diagram on the left shows that the feedback structure is blocked due to mutant nSyx. These network motifs are designed by CytoModeler based on the Cytoscape platform.