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Figure 6 | BMC Systems Biology

Figure 6

From: Bell-shaped and ultrasensitive dose-response in phosphorylation-dephosphorylation cycles: the role of kinase-phosphatase complex formation

Figure 6

Bell-shaped dose-response in the active phosphatase case (Figure2c). (a) Bell-shaped response in the zero-order regime when S t P t . Parameters used are: λ−1 = 10 s−1,λ1 = 1μ M−1s−1, k1 = 1 s−1,λ−2 = 10 s−1,λ2 = 20μ M−1s−1,k2 =1 s−1,λ−3 = 10 s−1,λ3 = 1μ M−1s−1,k3 = 100c s−1,κ−1 = 50 s−1,κ1 = 1μ M−1s−1,P t = 1μ M,S t = 10μ M. The Hill coefficient for the basic model is n H = 2. 15. (b) Bell-shaped response outside the zero-order regime when S t P t : λ−1 =10 s−1,λ1 = 1μ M−1s−1,k1 = 1 s−1,λ− 2= 10 s−1,λ2 = 20μ M−1s−1,k2 = 1 s−1,λ−3 = 10 s−1,λ3 = 1μ M−1s−1,k3 = 100 s−1,κ−1 = 50 s−1,κ1 = 1μ M−1s−1,P t = 1μ M,S t = 0. 1μ M. The Hill coefficient for the basic model is n H = 1. In (a)-(b), the full line corresponds to the basic model, the dashed line is numerical results for the extended model and the dotted line shows the tQSSA approximation.

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