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Figure 7 | BMC Systems Biology

Figure 7

From: Bell-shaped and ultrasensitive dose-response in phosphorylation-dephosphorylation cycles: the role of kinase-phosphatase complex formation

Figure 7

Robustness of the bell-shaped response. To illustrate the robustness of the bell-shaped response, the ratio of R max K t , the maximum of R with respect to K t , to R K t is calculated as multiple parameters are varied. The red regions correspond to parameter values with the largest bell-shaped response. (a) ω and P t are varied (κ−1as a variable in ω). (b) ω and M3 are varied (κ−1 as a variable in ω and λ3 as a variable in M3). Parameter values used in the extended model with only phosphatase active in (a) and (b): λ−1 = 10 s−1,λ1 = 1μ M−1s−1,k1 = 1 s−1,λ−2 = 10 s−1,λ2 = 20μ M−1s−1,k2 = 1 s−1,λ−3 = 10 s−1,λ3 = 1μ M−1s−1,k3 = 100 s−1,κ−1 = 10 s−1,κ1 = 1μ M−1s−1,P t = 1μ M,S t = 10μ M.

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