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Figure 8 | BMC Systems Biology

Figure 8

From: Bell-shaped and ultrasensitive dose-response in phosphorylation-dephosphorylation cycles: the role of kinase-phosphatase complex formation

Figure 8

Transient times to approach steady-state for the basic and extended model. Parameter values for the basic model: λ−1 = 10 s−1,λ1 = 1μ M−1s−1,k1 = 1 s−1,λ−2 = 10 s−1,λ2 = 20μ M−1s−1,k2 = 1 s−1,P t = 1μ M,S t = 10μ M. Parameter values for the extended model: λ−1 = 10 s−1,λ1 = 1μ M−1s−1,k1 = 1 s−1,λ−2 = 10 s−1,λ2 = 20μ M−1s−1,k2 = 1 s−1,κ−1 = 50 s−1,κ1 = 1μ M−1s−1,λ−3 = 10 s−1,λ3 = 1μ M−1s−1,k3 = 100 s−1,P t = 1μ M,S t = 10μ M. The transient times for R = ([S p ] + [S p P] + [S p PK])/S t were estimated such that the absolute difference between the positive steady-state and the time solution at the transient time is within a small tolerance and that the transient times do not change too much if the tolerance is varied. Hence, we chose the tolerance to be 10−4.

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