MetDP concept. The flowchart illustrates the conceptual framework (MetDP) for the prioritization of drug and drug targets against L. major. The first step deals with the association of L. major genes and drugs. The second step includes the prioritization of L. major targets and drugs using constraints such as druggability, gene essentiality and flux variability. The final step allows for the removal of toxic compounds from the prioritized list of drugs to yield a set of low-toxic candidate antileishmanials.