Table 2 The list of prioritized synthetic lethal targets
Gene#1 | Enzyme name | Druggability | No. of drugs | Gene#2 | Enzyme name | Druggability | No. of drugs | Avg. druggability |
|---|---|---|---|---|---|---|---|---|
LmjF27.2050 | ribonucleoside-diphosphate reductase small chain | 1 | 13 | LmjF22.1290 | ribonucleoside-diphosphate reductase small chain | 1 | 13 | 1 |
LmjF06.0860 | dihydrofolate reductase-thymidylate synthase | 1 | 76 | LmjF21.1210 | thymidine kinase | 0.8 | 10 | 0.9 |
LmjF20.0100 | phosphoglycerate kinase | 0.8 | 7 | LmjF24.0850 | triose-phosphate isomerase | 0.8 | 7 | 0.8 |
LmjF24.0850 | triose-phosphate isomerase | 0.8 | 7 | LmjF30.3380 | phosphoglycerate kinase | 0.5 | 7 | 0.65 |
LmjF04.0960 | adenylate kinase | 0.5 | 5 | LmjF34.0110 | adenylate kinase | 0.8 | 4 | 0.65 |
LmjF30.3520 | S-adenosylmethionine synthetase | 0.6 | 17 | LmjF30.3500 | S-adenosylmethionine synthetase | 0.6 | 17 | 0.6 |
LmjF05.0510 | F-type H+-transporting ATPase alpha chain | 0.5 | 2 | LmjF05.0500 | F-type H+-transporting ATPase alpha chain | 0.5 | 2 | 0.5 |
LmjF25.1180 | F-type H+-transporting ATPase beta chain | 0.5 | 3 | LmjF25.1170 | F-type H+-transporting ATPase beta chain | 0.5 | 3 | 0.5 |