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Table 2 The list of prioritized synthetic lethal targets

From: Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease

Gene#1 Enzyme name Druggability No. of drugs Gene#2 Enzyme name Druggability No. of drugs Avg. druggability
LmjF27.2050 ribonucleoside-diphosphate reductase small chain 1 13 LmjF22.1290 ribonucleoside-diphosphate reductase small chain 1 13 1
LmjF06.0860 dihydrofolate reductase-thymidylate synthase 1 76 LmjF21.1210 thymidine kinase 0.8 10 0.9
LmjF20.0100 phosphoglycerate kinase 0.8 7 LmjF24.0850 triose-phosphate isomerase 0.8 7 0.8
LmjF24.0850 triose-phosphate isomerase 0.8 7 LmjF30.3380 phosphoglycerate kinase 0.5 7 0.65
LmjF04.0960 adenylate kinase 0.5 5 LmjF34.0110 adenylate kinase 0.8 4 0.65
LmjF30.3520 S-adenosylmethionine synthetase 0.6 17 LmjF30.3500 S-adenosylmethionine synthetase 0.6 17 0.6
LmjF05.0510 F-type H+-transporting ATPase alpha chain 0.5 2 LmjF05.0500 F-type H+-transporting ATPase alpha chain 0.5 2 0.5
LmjF25.1180 F-type H+-transporting ATPase beta chain 0.5 3 LmjF25.1170 F-type H+-transporting ATPase beta chain 0.5 3 0.5
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BMC Systems Biology

ISSN: 1752-0509

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