Network analysis of global proteomic data from HCV infection of Huh-7.5 cells allows identification of targets. We constructed association networks from proteomics alone (A) or with added protein-protein interactions (B) as described in the text, varying parameters as indicated in (Additional file 3: Table S2). The top 20% of proteins ranked by the topological degree (blue diamonds), betweenness (red squares), clustering coefficient (green diamonds), and closeness (purple x's) were evaluated for their enrichment in proteins that are known interaction partners of pathogen proteins. Fold enrichment (Y axis) is calculated as the percentage of pathogen interactors in the group divided by the percentage not in the group. In panel B the circled points indicate the values for the PPI network alone. Statistical significance is indicated in (Additional file 3: Table S2).