Figure 6
Bottlenecks from cell culture-derived networks are enriched in proteins differentially regulated in HCV-positive patient samples. Bottlenecks were identified from a network derived from HCV infection of Huh-7.5 cells. The distribution of differential abundance values in proteomics from patient samples from the bottlenecks (red) versus non-bottlenecks (grey) are shown with the mean indicated by the dark line, the boxes are at 25th and 75th percentiles, and the dashed bars are at 1.5 time the interquartile range. P-values indicated are from a two-sided t test.