Figure 8

Overlap of predicted bottlenecks in networks from cell culture and patient data. Bottlenecks (top 10% or 20% as indicated) were identified for proteins in the networks derived from the HCV infected Huh-7.5 cell proteomic data and from liver biopsy samples from HCV-positive patients. Proteins (points) are plotted based on their betweenness centrality (number of paths passing through them) from the cell culture network (X axis) versus in the clinical network (Y axis). Boxes indicate a 10% or 20% threshold for bottleneck identification in both networks. Protein names for high-confidence shared bottlenecks are indicated.