Topological analysis of protein co-abundance networks identifies novel host targets important for HCV infection and pathogenesis

Table 1 Networks inferred from proteomics show significant enrichment in pathogen targets across many network inference parameters

	Measure	Group	Background	p-value	Fold-enrichment
^a CoA	Degree	18%	18%	1.6E-01	1.0
	Betweenness	20%	17%	1.4E-07	1.2
	Clustering Coefficient	19%	17%	7.1E-03	1.1
	Closeness	19%	17%	1.2E-02	1.1
CoA + PPI	Degree	35%	14%	2.2E-16	2.5
	Betweenness	46%	12%	2.2E-16	3.8
	Clustering Coefficient	31%	15%	2.2E-16	3.8
	Closeness	32%	15%	2.2E-16	2.1

^aCoA, co-abundance networks; CoA + PPI, co-abundance with protein-protein interactions

ISSN: 1752-0509