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Table 2 Conserved bottlenecks between cell culture and clinical samples

From: Topological analysis of protein co-abundance networks identifies novel host targets important for HCV infection and pathogenesis

Symbola ID Description Notesb
GSTK1 NM_015917 glutathione S-transferase kappa 1 M
IMMT NM_006839 inner membrane protein, mitochondrial (mitofilin) P, M
DCI NM_001919 dodecenoyl-Coenzyme A delta isomerase M
ATP5B NM_001686 ATP synthase, H + transporting M
YWHAQ NM_006826 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation P
HSPA8 NM_006597 heat shock 70 kDa protein 8 P, E
CALR NM_004343 calreticulin P, H, E
RPLP1 NM_001003 ribosomal protein, large, P1  
CYCS NM_018947 cytochrome c, somatic P, M
ETFA NM_000126 electron-transfer-flavoprotein, alpha M
HSPA9 NM_004134 heat shock 70 kDa protein 9 (mortalin) P
GOT2 NM_002080 glutamic-oxaloacetic transaminase 2 M, E
  1. aGenes appearing in the top 20% of bottlenecks ranked in both cell culture and clinical networks. These are also shown in the yellow and orange shaded regions of Figure 8
  2. bP, pathogen interactor; H, HCV target; M, mitochondrial protein; E, positive evolutionary selection