Topological analysis of protein co-abundance networks identifies novel host targets important for HCV infection and pathogenesis

Table 2 Conserved bottlenecks between cell culture and clinical samples

Symbol^a	ID	Description	Notes^b
GSTK1	NM_015917	glutathione S-transferase kappa 1	M
IMMT	NM_006839	inner membrane protein, mitochondrial (mitofilin)	P, M
DCI	NM_001919	dodecenoyl-Coenzyme A delta isomerase	M
ATP5B	NM_001686	ATP synthase, H + transporting	M
YWHAQ	NM_006826	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation	P
HSPA8	NM_006597	heat shock 70 kDa protein 8	P, E
CALR	NM_004343	calreticulin	P, H, E
RPLP1	NM_001003	ribosomal protein, large, P1
CYCS	NM_018947	cytochrome c, somatic	P, M
ETFA	NM_000126	electron-transfer-flavoprotein, alpha	M
HSPA9	NM_004134	heat shock 70 kDa protein 9 (mortalin)	P
GOT2	NM_002080	glutamic-oxaloacetic transaminase 2	M, E

^aGenes appearing in the top 20% of bottlenecks ranked in both cell culture and clinical networks. These are also shown in the yellow and orange shaded regions of Figure 8
^bP, pathogen interactor; H, HCV target; M, mitochondrial protein; E, positive evolutionary selection