Ensemble representation of EGF signalling network. Alternate signal transmission routes connecting the extracellular ligand EGF to the sentinel marker of pathway activity MAPK3 (ERK). Shortest paths (Ai), and total number of paths as a function of path length (Aii), color-coded by database source. (B) The “consensus” linear EGF pathway, with edges color-coded by source, plus additional connections through the ensemble network color-coded grey. Note the Ensemble network edges are derived from multiple sources, with all connections in the consensus pathway represented in at least 3 different databases.