Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in Drosophila melanogaster

Table 1 We have summarized body part(s), network motifs, triple genes, and GO terms for three periods (early, middle, and late stages)

Periods	Body parts	Network motif	Triple genes	GO term (p-value)
Early	Maternal	Motif 11	bcd, hb, kni	GO:0007354 (3.26e-06)
	dors ectoderm AISN	Motif 12	Kr, hb, gt	GO:0007354 (3.26e-06)
	vent ectoderm AISN
	procephalic ectoderm AISN
	dors ectoderm AISN	Motif 4	eve, en, zen	GO:0016564 (8.55e-05)
Middle	Post endoderm PR	Motif 4	tll, Kr, salm	GO:0045165 (2.10e-03)
	hindgut A	Motif 4	tll, hb, salm	GO:0001708 (5.11e-05)
	vent nerve cord PR P3	Motif 12	cas, Kr, nub	GO:0007402 (4.31e-08)
	vent nerve cord PR P3	Motif 12	Kr, hb, nub	GO:0007402 (5.29e-08)
	vent ectoderm PR	Motif 4	hb, en, eve	GO:0001709 (2.79e-04)
Late	clypeo-labral PR	Motif 6	odd, prd, en	GO:0007365 (9.40e-06)
	vent epidermis PR
	vent epidermis PR	Motif 6	nkd, en, wg	GO:0014016 (8.88e-06)
	clypeo-labral PR	Motif 6	slp1, en, wg	GO:0035289 (6.14e-07)
	vent epidermis PR
	dors epidermis PR
	brain	Motif 12	Kr, hb, nub	GO:0007402 (5.29e-08)
	vent nerve cord
	brain	Motif 7	gt, Kr, hkb	GO:0007354 (3.26e-06)
	brain		hb, Kr, Nos	GO:0001709 (3.21e-04)

Abbreviation: bcd (bicoid), cad (caudal), cas (castor), en (engrailed), eve (even slipped), gt (giant), hb (hunchback), kni (knirps), Kr (Kruppel), nkd (naked cuticle), Nos (nanos), nub (nubbin), odd (odd skipped), prd (paired), salm (spalt major), slp (sloppy paired), tll (tailless), wg (wingless), zen (zerknullt)
GO terms: GO:0007354 zygotic determination of anterior/posterior axis, embryo, GO:0016564 transcription repressor activity, GO:0045165 cell fate commitment, GO:0001708 cell fate specification, GO:0007402 ganglion mother cell fate determination, GO:0007365 periodic partitioning, GO:0014016 neuroblast differentiation, GO:0035289 posterior head segmentation.

ISSN: 1752-0509