Organizational structure and the periphery of the gene regulatory network in B-cell lymphoma

BMC Systems Biology

Table 5 Network similarity analysis for cellular components between the B-cell C3NET gene regulatory network and the Lenz and Salaverria gene regulatory network for 30 from the 58 cellular component subnetworks with the highest correlation coefficient of the betweenness centrality, significant in both comparisons - the columns denote the size (number of genes) of a Gene Ontology term represented in the subnetworks, betw _avg the average betweenness for the two comparisons, r _avg Spearman’s rank correlation coefficient and p _avg the FDR adjusted p-value

GOID	Term	Size	betw_avg	r _avg	pval_avg(FDR)
GO:0045178	basal part of cell	47	230	0.51	1.83e-03
GO:0035097	histone methyltransferase complex	126	187	0.37	1.98e-02
GO:0031967	organelle envelope	109	212	0.34	4.20e-03
GO:0034361	very-low-density lipoprotein particle	67	183	0.33	2.45e-02
GO:0055037	recycling endosome	82	167	0.31	1.38e-02
GO:0034364	high-density lipoprotein particle	169	172	0.28	2.23e-04
GO:0031461	cullin-RING ubiquitin ligase complex	429	183	0.25	1.17e-04
GO:0030017	sarcomere	325	235	0.24	7.26e-03
GO:0044422	organelle part	350	167	0.21	4.00e-04
GO:0005680	anaphase-promoting complex	295	156	0.20	6.33e-04
GO:0044441	cilium part	654	355	0.20	4.17e-07
GO:0005788	endoplasmic reticulum lumen	368	245	0.20	6.16e-03
GO:0044445	cytosolic part	625	354	0.19	3.01e-06
GO:0005665	DNA-directed RNA polymerase II, core complex	640	264	0.19	5.20e-05
GO:0005789	endoplasmic reticulum membrane	656	247	0.18	8.14e-06
GO:0005903	brush border	2234	414	0.17	2.09e-06
GO:0044432	endoplasmic reticulum part	983	410	0.17	1.43e-07
GO:0005765	lysosomal membrane	1894	338	0.17	2.12e-04
GO:0034703	cation channel complex	923	277	0.17	7.43e-07
GO:0071944	cell periphery	290	198	0.16	1.10e-02
GO:0035085	cilium axoneme	1586	261	0.16	2.62e-10
GO:0005769	early endosome	1585	329	0.16	1.76e-09
GO:0005773	vacuole	1585	285	0.16	2.62e-10
GO:0005768	endosome	1585	324	0.16	1.56e-02
GO:0044309	neuron spine	708	317	0.16	8.22e-05
GO:0044440	endosomal part	3021	287	0.16	1.44e-05
GO:0000313	organellar ribosome	1545	240	0.16	6.90e-04
GO:0005669	transcription factor TFIID complex	1480	308	0.15	5.94e-09
GO:0008305	integrin complex	1609	307	0.15	3.14e-09
GO:0008180	signalosome	1272	245	0.15	1.56e-02

ISSN: 1752-0509