The genetic control of growth rate: a systems biology study in yeast

BMC Systems Biology

Table 1 GO terms enriched among HFC control (see Additional File 4, Table S2 for complete list of GO terms)

	ENRICHED HAPLOINSUFFICIENT SET
GO ID	GO term	Ontology	Number of genes	FDR
GO:0005840	ribosome	CC	287	3.55E-018
GO:0030880	RNA polymerase complex	CC	31	6.83E-016
GO:0055029	nuclear DNA-directed RNA polymerase complex DNA-directed RNA polymerase II, core	CC	31	6.83E-016
GO:0005665	DNA-directed RNA polymerase II, core complex	CC	12	3.51E-014
GO:0016591	DNA-directed RNA polymerase ll, holoenzyme	CC	70	4.70E-012
GO:0032991	Macromolecular complex	CC	1538	4.22E-010
GO:0005736	DNA-directed RNA polymerase I complex	CC	14	4.23E-006
GO:0005832	chaperonin-containing T-complex	CC	11	1.57E-005
GO:0005666	DNA-directed RNA polymerase III complex	CC	17	2.18E-005
GO:0032200	telomere organization and biogenesis	BP	260	4.25E-005
GO:0042254	ribosome biogenesis and assembly	BP	334	9.79E-005
GO:0000119	mediator complex	CC	21	0.000265
GO:0005838	proteasome regulatory particle	CC	20	0.014216
GO:0030528	transcription regulator activity	MF	335	0.014216
GO:0004175	endopeptidase activity	MF	77	0.027946
	ENRICHED HAPLOPROFICIENT SET
GO ID	GO term	Ontology	Number of genes	FDR
GO:0007049	cell cycle	BP	552	0.002534
GO:0051320	S phase	BP	20	0.003251
GO:0006260	DNA replication	BP	151	0.010963
GO:0015932	nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity	MF	13	0.017113
GO:0000082	G1/S transition of mitotic cell cycle	BP	52	0.023716
GO:0005669	transcription factor TFIID complex	CC	14	0.034692
GO:0005685	snRNP U1	CC	15	0.035741
GO:0051052	regulation of DNA metabolic process	BP	41	0.043266
GO:0016020	membrane	CC	1592	0.044202
GO:0005991	trehalose metabolic process	BP	10	0.050603

ISSN: 1752-0509