Comparison of metabolic coherence and inconsistency measures for the adenoma data set. (a) The aldosterone-production inconsistency values are plotted against the MC of 69 tumor and control data sets. A clear negative correlation is visible (Pearson’s product-moment correlation coefficient r=−0.65, with p≤7×10−10determined by one-tailed t statistic, and Spearman’s rank correlation coefficient ρ=−0.72; t=1.9; l=0.95). (b) Dependency of the correlation on the threshold parameter (l=0.95). (c) Medium dependency of the negative correlation strength. Both Spearman’s rank correlation coefficient as well as Pearson’s correlation where computed for the MC and the inconsistency for 100 random growth media (t=1.9; l=0.95). The dashed line in (b) indicates the threshold parameter used in (a). Arrows in (c) indicate the correlation values found in (a).