AATAi**
|
unspecific
|
BN; IP
|
2-Aminoadipate transaminase;one out of two 2-oxoadipate producing reactions; missing GPR assoc. in all precursors.
|
SIaa, B1
|
PROD2*
|
unspecific
|
CD; CIL
|
Proline dehydrogenase; participates in a cycle that converts nadh to fadh2 (Figure 6); not expressed (Figure S5b).
|
SIaa, D3
|
DPMVDx
|
unspecific
|
CD
|
Diphosphomevalonate decarboxylase; essential step in the cholesterol biosynthesis pathway; not expressed; wrong or missing GPR assoc. (Figure S5c).
|
SIlip, B5
|
GLYK
|
unspecific
|
CIL
|
Glycerol kinase; not expressed in control and LIG, indicating that glycerol (provided in the in silico medium) might not be available as a in vivo medium component; slightly elevated expression levels in LIG (see Figure S5i).
|
SIlip, E5
|
PHETHPTOX2
|
unspecific
|
CIL
|
Phenylalanine 4-monooxygenase; converts phenylalanine (provided in the in silico medium) into tyrosine (not provided in the in silico medium); the high unspecific contribution strength indicates that tyrosine might be available as an in vivo medium component.
|
SIaa, A5
|
34HPPOR***
|
unspecific
|
CD; CIL
|
4-Hydroxyphenylpyruvate dioxygenase; involed in tryosine to fumarate and acetoacetate conversion; not expressed (see Figure S5m).
|
SIaa, B5
|
FUMtm
|
unspecific
|
—
|
Fumarate transport (cytosol/mitochondria); expression just below threshold (see Figure S5o).
|
no map
|
GLUTCOADHm**
|
specific
|
CD
|
Glutaryl-CoA dehydrogenase; involved in the 2-oxoadipate pathway (see Figure S5); elevated expression levels in LIG (see Figure S6a).
|
SIaa, A2
|
PDHm
|
specific
|
BN
|
Pyruvate dehydrogenase; entry point to the TCA cycle; elevated expression levels in LIG (see Figure S6c).
|
SIcarb, C3
|
MMEm
|
specific
|
CD
|
Methylmalonyl-CoA epimerase; involved in isoleucine degradation; slightly elevated expression levels in LIG (see Figure S6d).
|
SIaa, D1–E1
|
MEVK1x
|
specific
|
CD
|
Mevalonate kinase; an essential step in cholesterol biosynthesis; decreased expression levels in LIG and HIG (see Figure S6e).
|
SIlip, B5
|
G6PDH(1,2)rer
|
specific
|
–
|
Glucose-6-phosphate dehydrogenase; slightly elevated expression levels in LIG (see Figure S6f).
|
SIcarb, C4–D4
|
DHCR71r
|
specific
|
CD; COL
|
7-Dehydrocholesterol reductase; involved in cholesterol biosynthesis; slightly elevated expression levels in LIG (see Figure S6g).
|
SIlip, A4
|
HEX1
|
specific
|
CD; CIL
|
Hexokinase; first step in glycolysis; slightly elevated expression levels in LIG (see Figure S6h).
|
SIcarb, C4–C5
|
SQLEr
|
specific
|
CD
|
Squalene epoxidase; decreased expression levels in LIG and HIG (see Figure S6i).
|
SIlip, A5
|