Contributor | Category | Topological class | Biological interpretation | Reference |
---|---|---|---|---|
AATAi** | unspecific | BN; IP | 2-Aminoadipate transaminase;one out of two 2-oxoadipate producing reactions; missing GPR assoc. in all precursors. | SIaa, B1 |
PROD2* | unspecific | CD; CIL | Proline dehydrogenase; participates in a cycle that converts nadh to fadh2 (Figure 6); not expressed (Figure S5b). | SIaa, D3 |
DPMVDx | unspecific | CD | Diphosphomevalonate decarboxylase; essential step in the cholesterol biosynthesis pathway; not expressed; wrong or missing GPR assoc. (Figure S5c). | SIlip, B5 |
GLYK | unspecific | CIL | Glycerol kinase; not expressed in control and LIG, indicating that glycerol (provided in the in silico medium) might not be available as a in vivo medium component; slightly elevated expression levels in LIG (see Figure S5i). | SIlip, E5 |
PHETHPTOX2 | unspecific | CIL | Phenylalanine 4-monooxygenase; converts phenylalanine (provided in the in silico medium) into tyrosine (not provided in the in silico medium); the high unspecific contribution strength indicates that tyrosine might be available as an in vivo medium component. | SIaa, A5 |
34HPPOR*** | unspecific | CD; CIL | 4-Hydroxyphenylpyruvate dioxygenase; involed in tryosine to fumarate and acetoacetate conversion; not expressed (see Figure S5m). | SIaa, B5 |
FUMtm | unspecific | — | Fumarate transport (cytosol/mitochondria); expression just below threshold (see Figure S5o). | no map |
GLUTCOADHm** | specific | CD | Glutaryl-CoA dehydrogenase; involved in the 2-oxoadipate pathway (see Figure S5); elevated expression levels in LIG (see Figure S6a). | SIaa, A2 |
PDHm | specific | BN | Pyruvate dehydrogenase; entry point to the TCA cycle; elevated expression levels in LIG (see Figure S6c). | SIcarb, C3 |
MMEm | specific | CD | Methylmalonyl-CoA epimerase; involved in isoleucine degradation; slightly elevated expression levels in LIG (see Figure S6d). | SIaa, D1–E1 |
MEVK1x | specific | CD | Mevalonate kinase; an essential step in cholesterol biosynthesis; decreased expression levels in LIG and HIG (see Figure S6e). | SIlip, B5 |
G6PDH(1,2)rer | specific | – | Glucose-6-phosphate dehydrogenase; slightly elevated expression levels in LIG (see Figure S6f). | SIcarb, C4–D4 |
DHCR71r | specific | CD; COL | 7-Dehydrocholesterol reductase; involved in cholesterol biosynthesis; slightly elevated expression levels in LIG (see Figure S6g). | SIlip, A4 |
HEX1 | specific | CD; CIL | Hexokinase; first step in glycolysis; slightly elevated expression levels in LIG (see Figure S6h). | SIcarb, C4–C5 |
SQLEr | specific | CD | Squalene epoxidase; decreased expression levels in LIG and HIG (see Figure S6i). | SIlip, A5 |